Petrol | ||||
| S 550 (5.5 Mercedes-Benz M273 V8) | 382 hp / 281kW | Rear Wheel Drive | 2006-2011 | |
| S 550 4MATIC (5.5 Mercedes-Benz M273 V8) | 382 hp / 281kW | 4 Wheel Drive | 2006-2011 | |
| S 550 (4.7 Mercedes-Benz M278 V8) | 429 hp / 315kW | Rear Wheel Drive | 2011-2013 | |
| S 550 4MATIC (4.7 Mercedes-Benz M278 V8) | 429 hp / 315kW | 4 Wheel Drive | 2011-2013 | |
| S 600 (5.5 Mercedes-Benz M285 V12) | 510 hp / 375kW | Rear Wheel Drive | 2006-2013 | |
| S 63 AMG (6.2 Mercedes-AMG M156 V8) | 518 hp / 381kW | Rear Wheel Drive | 2007-2010 | |
| S 63 AMG (5.5 Mercedes-AMG M157 V8) | 536 hp / 394kW | Rear Wheel Drive | 2010-2013 | |
| S 63 AMG Perf. Pkg. (5.5 M-AMG M157 V8) | 563 hp / 414kW | Rear Wheel Drive | 2010-2013 | |
| S 65 AMG (6.0 Mercedes-AMG M275 V12) | 604 hp / 444kW | Rear Wheel Drive | 2006-2010 | |
| S 65 AMG (6.0 Mercedes-AMG M275 V12) | 621 hp / 457kW | Rear Wheel Drive | 2010-2013 | |
Diesel | ||||
| S 350 BlueTEC 4MATIC (3.0 M-B OM642 V6) | 240 hp / 176kW | 4 Wheel Drive | 2011-2013 | |
Mild Hybrid Petrol/Electricity | ||||
| S 400 Hybrid (3.5 Mercedes-Benz M272 V6) | 295 hp / 217kW | Rear Wheel Drive | 2009-2013 | |