Petrol | ||||
| E 350 (3.5 Mercedes-Benz M272 V6) | 268 hp / 197kW | Rear Wheel Drive | 2009-2011 | |
| E 350 4MATIC (3.5 Mercedes-Benz M272 V6) | 268 hp / 197kW | 4 Wheel Drive | 2009-2011 | |
| E 350 (3.5 Mercedes-Benz M276 V6) | 302 hp / 222kW | Rear Wheel Drive | 2011-2016 | |
| E 350 4MATIC (3.5 Mercedes-Benz M276 V6) | 302 hp / 222kW | 4 Wheel Drive | 2011-2016 | |
| E 400 (3.0 Mercedes-Benz M276 V6) | 329 hp / 242kW | Rear Wheel Drive | 2014-2017 | |
| E 400 4MATIC (3.0 Mercedes-Benz M276 V6) | 329 hp / 242kW | 4 Wheel Drive | 2014-2017 | |
| E 550 (5.5 Mercedes-Benz M273 V8) | 382 hp / 281kW | Rear Wheel Drive | 2009-2011 | |
| E 550 4MATIC (5.5 Mercedes-Benz M273 V8) | 382 hp / 281kW | 4 Wheel Drive | 2009-2011 | |
| E 550 (4.7 Mercedes-Benz M278 V8) | 402 hp / 296kW | Rear Wheel Drive | 2011-2017 | |
| E 550 4MATIC (4.7 Mercedes-Benz M278 V8) | 402 hp / 296kW | 4 Wheel Drive | 2011-2014 | |
| 5.5 Mercedes-AMG M157 V8 | 518 hp / 381kW | Rear Wheel Drive | 2011-2013 | |
| 6.2 Mercedes-AMG M156 V8 | 518 hp / 381kW | Rear Wheel Drive | 2009-2011 | |
| 5.5 Mercedes-AMG M157 V8 | 550 hp / 404kW | 4 Wheel Drive | 2013-2015 | |
| 5.5 Mercedes-AMG M157 V8 (Perf. Pkg.) | 550 hp / 404kW | Rear Wheel Drive | 2011-2013 | |
| 5.5 Mercedes-AMG M157 V8 (S-Model) | 577 hp / 424kW | 4 Wheel Drive | 2013-2016 | |
Diesel | ||||
| E 250 4MATIC (2.1 Mercedes-Benz OM651) | 195 hp / 143kW | 4 Wheel Drive | 2013-2016 | |
| E 250 BlueTEC (2.1 Mercedes-Benz OM651) | 195 hp / 143kW | Rear Wheel Drive | 2013-2016 | |
| E 350 BlueTEC (3.0 M-B OM642 V6) | 210 hp / 154kW | Rear Wheel Drive | 2010-2013 | |
Mild Hybrid Petrol/Electricity | ||||
| E 400 (3.5 Mercedes-Benz M276 V6) | 329 hp / 242kW | Rear Wheel Drive | 2012-2015 | |